I. Basic Research: Developing Azole-Related Small Molecule Anticancer Agents with Dual Mechanism of Actions in One Entity.

Overview: Polypharmacology has been receiving increasing attention as a novel strategy in drug development over the past decade. In contrast to the conventional one-drug/one-target approach, polypharmacology aims to develop drugs with multiple related targets or mechanisms of action to obtain more robust effects on diseases involving dysfunction of complex biological networks, such as cancer. This approach addresses some of the issues that can occur with multidrug chemotherapy, such as drug-drug interaction and poor medication compliance.

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Subprojects: i) Identification of Dual Acting Tyrosine Kinase Inhibitors.  ii) Developing anticancer Agents with Anti-inflammatory Agents.

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II. Research Education: Cancer Disparity Research, Education & Engagement: Mentoring Minority Cancer Researchers of Tomorrow:

 Overview: Disparities in health care based on race/ethnicity represent a mutable factor that costs the U.S. government billions of dollars annually. The Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity Center is a collaboration among Florida A&M University (FAMU, a Historically Black College and University {HBCU}), University of Florida (UF) and University of Southern California (USC) that will advance cancer research better to meet the needs of Black and Latino communities. In response to the Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) U54 PAR, the CaRE2 Health Equity Center Research Education Core (REC) is proposed to meet the cancer research education needs of underrepresented minorities (URM) in Florida and California, especially Blacks and Latinos.